The latest discovery of acute hepatitis in children of unknown cause: or related to the new coronavirus superantigen
 2022/05/17 | View:525

The latest discovery of acute hepatitis in children of unknown cause: or related to the new coronavirus superantigen



Recently, at least 348 cases of severe acute hepatitis of unknown cause in children have been reported in the UK, EU, US, Israel and Japan. Most children present with early gastrointestinal symptoms and later develop jaundice and, in some cases, acute liver failure. To the confusion of scientists, the hepatitis A, B, C, D and E viruses were not found in these children. The latest research shows that it may be related to the superantigen of the new coronavirus.

 

The so-called super antigen (SAg) is a class of substances that can activate a large number of T cell clones and generate a strong immune response with only a very low concentration (≤10-9 times M). Compared with ordinary antigens, superantigens do not require conventional intracellular antigen presentation and have no MHC restriction.

According to the difference of activated cells, superantigens can be divided into T cell superantigens and B cell superantigens, and according to their different sources, T and B cell superantigens can be divided into endogenous (viral) antigens and exogenous (viral) superantigens. bacterial type) superantigens.

 

According to reports from Israel, 12 unidentified childhood hepatitis cases have recently been reported in the country. The above cases came from different locations across the country and did not show the characteristics of clustered infection. The main symptoms are severe liver infection and marked elevation of liver enzymes, usually accompanied by jaundice, and gastrointestinal symptoms in some cases. At present, these cases have all been discharged. Among them, 2 cases at Schneider Children's Hospital underwent liver transplantation due to liver failure, and the remaining cases improved rapidly after receiving steroid drug treatment.

 

Of the 12 cases identified in Israel, 11 had contracted the virus within a year. Although there is no clear evidence that the unidentified hepatitis is related to the new coronavirus, several Israeli medical experts have expressed doubts in interviews with the media that there is a link between the two. Glasberg, director of the Pediatric Liver Transplant Center at Schneider Children's Medical Center, said that after ruling out all possibilities, all the cases found had in common that they were infected with the new coronavirus about three and a half months before the onset of hepatitis. Severe COVID-19 infection is known to damage the liver, so this unidentified hepatitis may be one of the long-term symptoms of COVID-19.


Get In Touch

Quick Response within 24 hours!

name*
email*
tel
mess*

Contact Us

  • 电话Tel: (+)86-519-88168398

  • whatsappWhatsApp: +86-13961432323

  • 邮箱Email: sale01@lelun.com

  • 地图HengShanQiao Town, out of East Gate, Changzhou ,Jiangsu, China

About Us

Changzhou Medical Appliances General Factory Co., Ltd. was built in 1988, it is a modern factory specialized in producing the disposable medical appliances in China. The factory is only 1km to Hengshan entrance of Huning high-speed road and is about 20 miles to Changzhou airport. So the traffic is convenience.
The area of the factory is 40000㎡, the area of purifying workshop is 7000m, and fixed assets are about 5,000,000USD. Our main products are Disposable infusion sets, Disposable blood transfusion sets, Disposable Sterile syringe sets, latex glove, disposable infusion set, simple oxygen mask, nebulizer mask, urine cup, hernia mesh, urine bag etc. Now we can manufacture more than 200,000,000 sets per year.

CopyRight © 2023-2024   Changzhou Medical Appliances General Factory Co.,Ltd  All rights reserved   Sitemap   All tags   Designed by Zhonghuan Internet
Get The Latest Product Information
From the beginning, we puts customer service first around the world, the most professional processor and supporters you can trust. This is our comprehensive commitment to quality.
Company Name
*
This field is required
Email
*
This field is required
Email format error
Phone
This field is required
Telephone information is wrong!
Message
*
This field is required
Send Message